Annie Alexander had been in practice for over a decade in 1903, when the local physicians organized themselves into the Mecklenburg County Medical Society. She evidently welcomed this step towards professionalization, for she was one of the charter members, as was her father. “Annie L. Alexander” was the second person to sign the roster. Dr. Annie Alexander must have won the respect of the male physicians of Charlotte, for she served as the first Secretary-Treasurer of the Medical Society.