Based on correspondence between herself and her father, Annie's home town of Charlotte, NC, was never a consideration as a place to start a practice. In the summer of 1884, she wrote the following to Dr. J. B. Alexander: “I can’t decide where to locate when I leave Philadelphia. I’ve thought of Baltimore, Atlanta, and Jacksonville, but there will be obstacles wherever I locate. My success will depend on my ability and the liberal views of the people among whom I will be.”