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From the Charlotte Home Democrat, May 29, 1885:

"Miss Annie Lowrie Alexander of Mecklenburg County passed an examination before the Board of Medical Examiners in Durham and was admitted as a member of the North Carolina Medical Association."

One of her first actions as a professional doctor was to deliver a lecture at the Farmer's Institute in Concord, Cabarrus County in 1887.

It did not take long for the young doctor to establish her practice on North Tryon Street. She advertised her services, and the local residents started to refer to her as "Dr. Annie." She drove her buggy with her faithful horse, Conrad, all over the city and county attending women and children.